Name | Methyl indole-6-carboxylate |
Synonyms | RARECHEM AL BF 1265 Methyl indole-6-carboxylate METHYL INDOLE-6-CARBOXYLATE methyl 1H-indole-6-carboxylate METHYL 1H-INDOLE-6-CARBOXYLATE Methyl indole-6-carboxylic acid Indole-6-carboxylic acid methyl ester INDOLE-6-CARBOXYLIC ACID METHYL ESTER 1H-Indole-6-carboxylic Acid Methyl Ester 1H-Indole-6-carboxylic acid, methyl ester |
CAS | 50820-65-0 |
EINECS | 610-576-0 |
InChI | InChI=1/C10H9NO2/c1-13-10(12)8-3-2-7-4-5-11-9(7)6-8/h2-6,11H,1H3 |
Molecular Formula | C10H9NO2 |
Molar Mass | 175.18 |
Density | 1.253±0.06 g/cm3(Predicted) |
Melting Point | 76-80 °C (lit.) |
Boling Point | 331.7±15.0 °C(Predicted) |
Flash Point | 154.4°C |
Solubility | Chloroform, Methanol |
Vapor Presure | 0.000153mmHg at 25°C |
Appearance | Brown powder |
Color | White to pale brown |
BRN | 141837 |
pKa | 15.80±0.30(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Sensitive | Sensitive to air |
Refractive Index | 1.639 |
MDL | MFCD00211063 |
Physical and Chemical Properties | White to light yellow solid |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
HS Code | 29339900 |
Hazard Class | IRRITANT |
Nature:
-Appearance: Methyl indole-6-carboxylate is a colorless or pale yellow liquid.
-Solubility: It can be dissolved in organic solvents, such as ethanol, ether and dichloromethane.
Use:
-Chemical research: It can be used in organic synthesis reactions, for example, as a protecting group for indole.
Preparation Method:
Methyl indole-6-carboxylate can be prepared by esterifying indole with methyl chloroformate. Specific steps are as follows:
1. Under alkaline conditions, indole is reacted with methyl chloroformate.
2. After completion of the reaction, the resulting product is purified by operations such as extraction and washing.
Safety Information:
- Methyl indole-6-carboxylate may be irritating and irritating to the eyes in pure liquid form. Therefore, you should pay attention to using protective gloves and goggles when contacting, and make sure to work in a well-ventilated place.
-It should not be in direct contact with the skin, and inhalation of its vapor or splashes should be avoided.
-During storage, the Methyl indole-6-carboxylate should be kept in an airtight container in a cool, dry place away from sources of fire.